FIELD: chemistry.
SUBSTANCE: invention relates to the field of immunology, biochemistry and molecular biology. Proposed is a peptide YDPEYRNFWGCG (SEQ ID NO: 1) able to specifically bind (interact) with the immune response control molecule CTLA-4 and regulate biological activity of the CTLA-4 inhibitory receptor.
EFFECT: peptide can be used to assess the expression of the CTLA-4 (CD152) receptor in patients and to control the quality during production of recombinant proteins, as well as in development of pharmaceutical formulations of the peptide preparation for treatment of immune pathologies, autoimmune or oncologic diseases and HIV infection.
1 cl, 3 ex, 6 dwg
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Year |
Author |
Number |
| TETRADECAPEPTIDE ANTAGONIST OF INTERACTION CTLA-4 WITH B7-1 |
2021 |
- Podlesnykh Stepan Vasilevich
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|
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|
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1998 |
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|
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1999 |
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|
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|
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2006 |
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|
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1999 |
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|
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- Friman Gordan
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|
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2010 |
- Kueva, Kristof
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|
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