FIELD: biotechnology, microbiology, vaccines.
SUBSTANCE: invention can be used in preparing vaccines used for inducing immune response in animals. Invention proposes immunogenic conjugate of polusaccharide from Haemophilus influenzae of type B (Hib) with practically replaced external membrane mature protein of class 2 or 3 from Neisseria meningitides or its fusion form comprising amino acids 1-20 or 1-22 of capside protein 
of gene T7 (xPorB). Hib is subjected for oxidation or selective hydrolysis for preparing aldehyde groups. Then this polysaccharide with xPorB is conjugated by reductive amination. The prepared conjugate is used for preparing pharmaceutical composition and induction of immune response in animal with regards to H. influenzae.
EFFECT: improved preparing method, valuable biological and medicinal properties of conjugate.
13 cl, 16 dwg, 5 ex
| Title |
Year |
Author |
Number |
| NUCLEIC ACIDS, CODING RECEPTOR CTLA-4 OF CAT, VECTORS, HOST CELLS, VACCINES, OLIGONUCLEOTIDES, POLYPEPTIDES CTLA-4 OF CAT AND METHODS FOR INDUCTION AND SUPPRESSION OF IMMUNE RESPONSE IN CAT |
1999 |
- Kollison Ehllen V.
- Choj In-Soo
- Uinslou Barbara Dzh.
- Kochran Mark D.
|
RU2377302C2 |
| IMMUNOGENIC CONJUGATE OF BETA-PROPIONAMIDE-BOUND POLYSACCHARIDE WITH PROTEIN APPLIED AS VACCINE |
1999 |
- Mishon Fransis
- Khuang Chun-Khsien
- Uitz Katrin
|
RU2249463C2 |
| METHOD FOR PRODUCING CAPSULAR HAEMOPHILUS INFLUENZAE TYPE B POLYSACHHARIDE, APPLICATION OF CAPSULAR POLYSACCHARIDE AND METHOD FOR PRODUCING VACCINE FORMULATIONS |
2013 |
- Le Ir Zherom
- Luber Paskal
- Barbirato Faben
- Lindli Nikolas
|
RU2644246C2 |
| COMBINED VACCINES WITH WHOLE CELL PERTUSSIS ANTIGEN |
2006 |
- Kontorni Mario
- Mannuchchi Donatella
|
RU2420315C2 |
| RECOMBINANT VIRUS EXPRESSING FOREIGN DNA ENCODING FELINE CD80, FELINE CTLA-4 OR FELINE CD86 AND ITS APPLYING |
1999 |
- Uinslou Barbara Dzh.
- Kokran Mark D.
|
RU2244006C2 |
| PEPTIDE ABLE TO SPECIFICALLY BOND WITH CTLA-4 IMMUNE RESPONSE CONTROL MOLECULE |
2020 |
- Podlesnykh Stepan Vasilevich
- Shapoval Andrej Ivanovich
|
RU2747793C1 |
| COMBINED BACTERIAL MENINGITIS VACCINES TO BE INTRODUCED THROUGH MUCOUS MEMBRANE |
2003 |
|
RU2378008C2 |
| TETRADECAPEPTIDE ANTAGONIST OF INTERACTION CTLA-4 WITH B7-1 |
2021 |
- Podlesnykh Stepan Vasilevich
- Shapoval Andrej Ivanovich
|
RU2757418C1 |
| COMBINED VACCINE CONTAINING DIPHTHERIA, TETANUS, ACELLULAR PERTUSSIS, HAEMOPHILUS INFLUENZAE AND POLIOVIRUS ANTIGENS, USING IT AND METHOD FOR PREPARING IT |
2009 |
- Dzhain Radzhesh
- Singkh Sukkhdzhit
- Zhdambu Lavit
|
RU2526214C2 |
| MULTIPLE VACCINATION INCLUDING SEROGROUP C MENINGOCOCCI |
2006 |
|
RU2457858C2 |
