INDOL(SULFONIL)-N-HYDROXYBENZAMIDE DERIVATIVES AS SELECTIVE HDAC INHIBITORS Russian patent published in 2021 - IPC C07D209/40 C07D409/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of sulfonylhydroxamic acid of a general formula I which can be used as selective inhibitors of histone deacetylases (HDAC). In the general formula I, the ring A constitutes phenyl, naphthalenyl and benzothiophenyl; the ring B constitutes phenyl; R₁ constitutes alkyl; R₂, R₃ constitute hydrogen, alkoxy, halogen, nitro, benzyloxy, phenyl, CF₃; R₄, R₅, R₆ constitute hydrogen; X=O. The invention also relates to a method of synthesis of the described compounds and use thereof as selective HDAC inhibitors.

EFFECT: achieved is synthesis of compound which can be used as selective HDAC inhibitor.

15 cl, 3 dwg, 3 tbl, 18 ex