NOVEL 4-AMINO-N-HYDROXYBENZAMIDES AS HDAC INHIBITORS FOR TREATING CANCER Russian patent published in 2016 - IPC C07D207/27 C07D207/48 C07D401/04 C07D403/04 C07D403/10 C07D413/10 C07D471/04 A61K31/4015 A61K31/402 A61K31/4025 A61K31/407 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to the HDAC inhibitors of formula (I) or pharmaceutically acceptable salts, esters or stereoisomers, where R¹ represents hydrogen or halogen; R² represents hydrogen, C_1-4-alkyl; R³ is phenyl, unsubstituted or substituted with one or two or three times a halogen, C_1-4-alkyl, C_1-4-alkoxy, C_1-4-alkylsulfonyl, cyano, trifluoromethyl, phenyl, phenoxy, pirrolyl, imidazonyl, oxazolyl or di C_1-4-alkylamino-C_1-4-alkoxy; naphthalenyl; quinolinyl; C_3-7-cycloalkyl; phenylalkyl, where phenyl may not be substituted by or once or twice substituted by halogen, C_1-4-alkoxy, phenyl; naftalinilalkyl; phenylcycloalkyl; pyrimidinyl; phenylsulfonyl, where phenyl may not be substituted by or once or twice substituted by halogen, phenyl; or phenylcarbonyl, where phenyl may not be substituted by or once or twice substituted by halogen, C_1-4-alkoxy; R⁴ is hydrogen or C_1-4-alkyl; Y represents -CH₂- or -C=O; or R⁴ and Y together with carbon atom to which R⁴ is connected, can form a phenyl ring or a pyridine ring, which may not be substituted with or substituted with halogen; provided that R² is C_1-4alkyl; A represents -C=O, -CH₂- or -CH-alkyl, provided that a and Y simultaneously does not represent -C=O.

EFFECT: presented are pharmaceutical compositions of these compounds and use thereof as drug for treating cancer.

14 cl, 3 tbl, 101 ex