2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3,5]NONANE DERIVATIVES AND USE THEREOF AS GHRELIN RECEPTOR ANTAGONISTS OR INVERSE AGONISTS Russian patent published in 2014 - IPC C07D471/10 C07D519/00 A61K31/4747 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) where R¹ is phenyl, imidazo[2,1-b][1,3]thiazolyl, pyridinyl, pyrazolo[1,5-a]pyridinyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, imidazo[2,1-b][1,3,4]thiadiazolyl, 1H-indazolyl, pyridazinyl, imidazo[1,2-b][1,2,4]triazinyl, 1H-pyrazolo[3,4-b]pyridinyl, imidazo[1,2-b]pyridazinyl, 2,3-dihydro[1,4]dioxino[2,3-b]pyridinyl, oxadiazolyl or imidazo[1,2-a]pyridinyl; each of which is optionally substituted with 1-3 substitutes, independently selected from methyl, methoxy, cyano, cyclopropyl, -C(O)NH₂ and -NHC(O)CH₃; R^a in each case is hydrogen; each of Z, Z¹ and Z² is independently CH; L is a direct bond; and R² is hydrogen, phenyl, phenoxy, pyrimidinyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, pyridinyl, oxazolyl, oxadiazolyl, pyrazolyl, pyridazinyl, triazinyl or pyrazinyl, each optionally substituted with 1-3 substitutes independently selected from methyl, trifluoromethyl, ethyl, methoxy, cyano or -C(O)NH₂; or pharmaceutically acceptable salts thereof, which act as ghrelin antagonists or inverse agonists.

EFFECT: obtaining novel derivatives.

13 cl, 1 dwg, 11 tbl, 11 ex