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2 749 248

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IPC

A61K39/395(2006-01-01)

A61P19/02(2006-01-01)

C12Q1/6851(2018-01-01)

C12Q1/686(2018-01-01)

C12Q1/6883(2018-01-01)

G01N33/50(2006-01-01)

(21) (22)

Application

2020131968, 2020-09-28

(24)

Start date

2020-09-28

(22)

Actual filing date

2020-09-28

(45)

Published

2021-06-07

(72)

Inventor

Zamiatnin Andrei AleksandrovichBure Irina VladimirovnaNemtsova Marina ViacheslavovnaMikhailenko Dmitrii SergeevichKuznetsova Ekaterina BorisovnaLemak Mariia StepanovnaTarasov Vadim Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Pervyi Moskovskii Gosudarstvennyi Meditsinskii Universitet Imeni I.M. Sechenova Ministerstva Zdravookhraneniia Rossiiskoi Federatsii Universitet) Vo Pervyi Mgmu Im. I.M. Sechenova Minzdrava Rossii Universitet)

METHOD FOR PREDICTING EFFECTIVENESS OF TREATMENT OF RHEUMATOID ARTHRITIS WITH DRUG OLOKIZUMAB USING EPIGENETIC MARKERS Russian patent published in 2021 - IPC A61K39/395 A61P19/02 C12Q1/6851 C12Q1/686 C12Q1/6883 G01N33/50

Abstract RU 2749248 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine and namely to genetics and rheumatology and can be used to predict effectiveness of treatment of rheumatoid arthritis with olokizumab. The level of expression of epigenetic markers in blood plasma obtained from a patient with rheumatoid arthritis is determined: miR-26b, miR-451, miR-522. With the obtained values miR-26b <-13.92, miR-451 <-12.08, miR-522 <-17.46 an effective clinical response to olokizumab therapy is predicted.

EFFECT: method makes it possible to predict effectiveness of rheumatoid arthritis treatment with olokizumab by determining predictors of development of an effective clinical response to olokizumab treatment in patients with rheumatoid arthritis - epigenetic markers.

1 cl, 1 dwg, 4 tbl, 3 ex

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RU 2 749 248 C1

Authors

Zamiatnin Andrei Aleksandrovich

Bure Irina Vladimirovna

Nemtsova Marina Viacheslavovna

Mikhailenko Dmitrii Sergeevich

Kuznetsova Ekaterina Borisovna

Lemak Mariia Stepanovna

Tarasov Vadim Vladimirovich

Dates

2021-06-07—Published

2020-09-28—Filed