FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to rheumatology and concerns the prediction of the effectiveness of methotrexate therapy in patients with rheumatoid arthritis (RA). To do this, the level (L) of the relative expression of the AMP activated protein kinase (AMPK) gene in the blood of RA patients is determined in comparison with the average expression of the AMPK gene in healthy individuals. When the value of L≥3.83 is obtained, high efficacy of methotrexate therapy is predicted.
EFFECT: provides high accuracy in predicting the response to methotrexate therapy in RA patients who have not previously received this drug, and timely prescription of individual therapy adequate to the clinical situation.
1 cl, 1 dwg, 6 tbl, 3 ex
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