VECTOR Russian patent published in 2021 - IPC A61K48/00 A61P25/08 A61P25/16 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and concerns a recombinant adeno-associated viral (rAAV) vector for the expression of neuropeptide Y and neuropeptide Y2 receptor in cells of the central nervous system, containing a sequence encoding neuropeptide Y (NPY) and a sequence encoding neuropeptide Y2 receptor (NPY2R), and the specified sequence encoding NPY2R is located in the 5’-3’ direction from the sequence encoding NPY. The group of inventions also concerns an AAV particle containing the specified vector for the expression of neuropeptide Y and neuropeptide Y2 receptor in cells of the central nervous system; a pharmaceutical composition containing an AAV particle for the prevention, inhibition, relief or treatment of epilepsy or Parkinson's disease in a mammal; a method for treating, inhibiting, or alleviating epilepsy or Parkinson's disease in a subject, including injecting into the cells of the central nervous system of a subject suffering from epilepsy or Parkinson's disease, a pharmacologically effective amount of the said composition.

EFFECT: group of inventions provides safe expression with high efficiency and reduced duration of seizures.

39 cl, 9 dwg, 3 tbl, 1 ex