FIELD: biotechnology.
SUBSTANCE: following is presented: a product containing the cofactor of complement factor I (CFI) and complement factor I (CFI) or nucleotide sequences encoding them, in the form of a combination preparation for simultaneous, separate or sequential use in therapy, an isolated polynucleotide encoding the cofactor of complement factor I (CFI) and complement factor I (CFI), an expression vector and host cells that produce the cofactor complement factor I (CFI) and complement factor I (CFI). Also the following is disclosed: a pharmaceutical composition for treating or preventing a complement-mediated ocular disorder, a method of treating or preventing a complement-mediated ocular disorder, and a method of delivering cofactor complement factor I (CFI) and complement factor (CFI) to the eye of a subject.
EFFECT: invention is used for the treatment of eye disorders.
40 cl, 11 dwg, 2 tbl, 6 ex
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