FAST DECORING PHARMACEUTICAL COMPOSITION Russian patent published in 2021 - IPC A61K31/4985 A61K31/519 A61K38/95 A61K31/47 A61K31/404 A61K47/36 A61K47/61 

FIELD: medicine.

SUBSTANCE: inventions group relates to the field of medicine, namely to a rapidly disintegrating oral pharmaceutical composition comprising an open matrix cellular structure carrying one or more pharmaceutically active ingredients, where the open matrix cellular structure includes 40-99% maltodextrin and 0.99-5% hyaluronic acid or its sodium salt, based on the total weight of the open matrix cellular structure and the material carried by the open matrix cellular structure, also relates to a rapidly disintegrating oral pharmaceutical composition comprising a matrix carrying one or more pharmaceutically active ingredients, the matrix disintegrating upon contact with an aqueous medium, said matrix comprising 40-99% maltodextrin and 0.99-5% hyaluronic acid or its sodium salt, based on the total weight of the matrix and the material carried by the matrix, also relates to a method for preparing a rapidly disintegrating oral pharmaceutical composition comprising sublimating a solvent from a solidified liquid preparation comprising one or more pharmaceutically active ingredients, maltodextrin and hyaluronic acid or its sodium salt in a solvent, and a method for preparing a rapidly disintegrating oral pharmaceutical composition comprising: (a) obtaining a liquid preparation comprising maltodextrin, hyaluronic acid or its sodium salt and one or more active ingredients in a solvent; (b) freezing said liquid preparation; (c) sublimating the solvent from the frozen preparation to obtain a pharmaceutical composition, wherein the pharmaceutical composition disintegrates within 30 seconds upon contact with an aqueous medium.

EFFECT: invention provides the creation of a pharmaceutical composition having a high tensile strength and demonstrating rapid disintegration in an aqueous medium.

17 cl, 5 dwg, 1 tbl, 11 ex