PREVENTION AND TREATMENT OF MIGRAINE Russian patent published in 2021 - IPC A61K31/47 A61K31/191 A61K31/197 A61P25/06 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to the use of a compound and to the use of a pharmaceutical composition containing the compound in a method for treating or preventing migraine and/or its symptoms, where the compound is selected from: a) beta-hydroxybutyric acid (βHB) or its pharmaceutically acceptable salt, b) acetoacetate (AcAc) or its pharmaceutically acceptable salt, c) metabolic precursor of βHB or AcAc, where the specified metabolic precursor is 1,3-butanediol (CAS No. 107 88 0) or its pharmaceutically acceptable salt, and d) a compound containing an acetoacetyl or 3-hydroxybutyrate fragment described by one of the following: D-beta-hydroxybutyrate-D-1,3-butanediol, (3R)-hydroxybutyl-(3R)-hydroxybutyrate, acetoacetyl-1,3-butanediol, acetoacetyl-R-3-hydroxybutyrate and acetoacetylglycerin, or described by one of the following formulas:

, , , , , , , , ,

or its pharmaceutically acceptable salt.

EFFECT: group of inventions provides development of new therapeutic agents for the treatment of migraine, demonstrating improved effectiveness and reduced side effects.

22 cl, 8 dwg, 1 tbl