IMPROVED THERAPEUTIC INDEX OF INHIBITORS AGAINST IMMUNE CHECKPOINT USING COMBINATION THERAPY INCLUDING PHY906 EXTRACT, SCUTELLARIA BAICALENSIS GEORGI (S) EXTRACT OR COMPOUND OF SUCH EXTRACTS Russian patent published in 2021 - IPC A61K36/484 A61K36/53 A61K36/539 A61K36/65 A61K36/725 A61K39/39 A61P35/00 

Abstract RU 2753523 C2

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a kit for the treatment of cancer and to a method for the treatment of cancer. A cancer treatment kit, where the cancer is at least one selected from a group consisting of melanoma, non-small cell lung cancer, renal cell cancer, liver cancer, colon cancer, urothelial bladder cancer and pancreatic cancer, includes one or several immune checkpoint inhibitors selected from a group consisting of therapeutically effective amounts of anti-PD1 and anti-PD-L1, and at least one medicinal plant-based composition selected from a group consisting of (a) therapeutically effective amount of an aqueous plant extract of Scutellaria baicalensis (S), (b) therapeutically effective amount of a PHY906 plant extract, which includes aqueous plant extracts of Scutellaria baicalensis (S), Glycyrrhiza uralensis (G), Paeonia lactiflora (P) and Ziziphus jujuba (Z). A method for the treatment of cancer in a subject includes the injection of therapeutically effective amount of at least one medicinal plant-based composition selected from a group consisting of (a) therapeutically effective amount of an aqueous plant extract of Scutellaria baicalensis (S), (b) therapeutically effective amount of a PHY906 plant extract, which includes aqueous plant extracts of Scutellaria baicalensis (S), Glycyrrhiza uralensis (G), Paeonia lactiflora (P) and Ziziphus jujuba (Z), where the subject is additionally injected with one or several immune checkpoint inhibitors selected from a group consisting of anti-PD1 and anti-PD-L1, where the cancer is at least one selected from a group consisting of melanoma, non-small cell lung cancer, renal cell cancer, liver cancer, colon cancer, urothelial bladder cancer and pancreatic cancer.

EFFECT: above-mentioned kit expresses an increased synergetic effect relatively to the treatment of cancer selected from a group consisting of melanoma, non-small cell lung cancer, renal cell cancer, liver cancer, colon cancer, urothelial bladder cancer and pancreatic cancer.

18 cl, 8 dwg, 8 ex

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RU 2 753 523 C2

Authors

Cheng, Yung-Chi

Chen, Lieping

Dates

2021-08-17Published

2017-05-23Filed