TREATING LUNG CANCER BY COMBINATION OF ANTI-PD-1 AND OTHER ANTI-CANCER AGENTS Russian patent published in 2019 - IPC A61K39/395 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to oncology, and can be used in treating lung cancer. Method according to the invention involves administering to a subject a combination of nivolumab and a two-component platinum-based (PT-DC) based chemotherapy, wherein PT-DC is a combination of gemcitabine in dose of 1250 mg/m² and cisplatin in dose of 75 mg/m²; combination of pemetrexed in dosage 500 mg/m² and cisplatin in dose of 75 mg/m²; or a combination of paclitaxel in dose of 200 mg/m² and carboplatin in dose providing desired area under curve 6 mg/ml/min (AUC6), wherein PT-DC is administered simultaneously with nivolumab within 4 doses of nivolumab, followed by repeated administration of nivolumab separately. Kit according to the invention comprises doses of nivolumab and PT-DC and instructions for use thereof.

EFFECT: use of inventions enables higher anti-tumour activity of nivolumab, increases overall survival of the patients, reduces tumour mass by the combination.

16 cl, 23 dwg, 37 tbl, 6 ex