NOVEL APPROACH TO CANCER TREATMENT USING IMMUNOMODULATION Russian patent published in 2024 - IPC A61K31/69 A61K39/395 A61K45/08 A61P35/00 A61P37/04 

FIELD: medicine.

SUBSTANCE: declared invention relates to the field of medicine, in particular to oncology, and discloses a method for enhancing the immune response in a subject suffering from cancer, comprising administering to the subject an effective amount of thalabostat or a pharmaceutically acceptable salt thereof in combination with an anti-PD-L1 antibody, wherein the thalabostat or its pharmaceutically acceptable salt is administered in dose of 0.001 mg/kg to 10 mg/kg and the anti-PD-L1 antibody is administered in dose of 0.01 mg/kg to 30 mg/kg.

EFFECT: synergistic anticancer action of a selective dipeptidyl peptidase inhibitor together with an immune checkpoint inhibitor.

24 cl, 8 tbl, 9 dwg, 1 ex