FIELD: biotechnology.
SUBSTANCE: described combination for preventing or treating cancer caused by human papilloma virus (HPV), and a method of using the combination. This combination contains human papilloma virus (HPV) vaccine and a checkpoint inhibitor agent for preventing or treating cancer caused by human papilloma virus (HPV), where the HPV vaccine is the HPV vaccine containing the nucleic acid construct SEQ ID NO: 15 or a functional version with 85% or more sequence identity with SEQ ID NO: 15, and the dose of the HPV vaccine is 0.5 mg to 5 mg, and wherein the checkpoint inhibitor agent is an anti-PD-1 antibody, and the dose of the anti-PD-1 antibody is 50 to 500 mg.
EFFECT: disclosed is a method of treating cervical cancer.
16 cl, 18 dwg, 2 ex
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