FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to molecular biology and pharmacology. What is presented is a method for the prediction of the pharmaceutical effectiveness of adalimumab for treating rheumatoid arthritis, wherein the method involves measuring a level of at least one of ADAMTS4 iRNA and ADAMTS5 iRNA in a sample taken from a subject, and determining if adalimumab is effective for rheumatoid arthritis in a subject on the basis of a level of at least one of ADAMTS4 iRNA and ADAMTS5 iRNA considered as a value.
EFFECT: method may be used in medicine in treating rheumatoid arthritis.
3 cl, 2 dwg, 8 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL METHOD OF DIAGNOSING RHEUMATOID ARTHRITIS AND SET FOR RHEUMATOID ARTHRITIS DIAGNOSTICS | 2011 |
|
RU2554751C2 |
| METHODS AND COMPOSITIONS FOR DIAGNOSTICS OF ANKYLOSING SPONDYLITIS WITH APPLICATION OF BIO-MARKERS | 2006 |
|
RU2438704C2 |
| METHODS OF DIAGNOSING AND TREATING RHEUMATOID ARTHRITIS | 2020 |
|
RU2828027C2 |
| METHOD FOR DETERMINING ANTI-DRUG ANTIBODY ISOTYPE | 2011 |
|
RU2574976C2 |
| AUTOMATIC INJECTION DEVICE | 2007 |
|
RU2438721C2 |
| METHOD FOR PREDICTING THE EFFECTIVENESS OF METHOTREXATE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS | 2020 |
|
RU2753793C1 |
| AUTOMATIC INJECTOR | 2007 |
|
RU2575906C2 |
| IMPROVED HIGH-CONCENTRATED LIQUID PREPARATIONS OF ANTIBODIES AGAINST TNF-ALPHA | 2011 |
|
RU2639386C2 |
| METHOD OF DETECTING ANTI-TNF PREPARATIONS AND AUTOANTIBODIES | 2010 |
|
RU2571489C2 |
| COMPOSITIONS FOR RHEUMATOID ARTHRITIS TREATMENT AND METHODS OF THEIR APPLICATION | 2012 |
|
RU2664697C2 |
