SALTS AND SOLID FORMS OF MONOBACTAM ANTIBIOTIC Russian patent published in 2021 - IPC C07D417/14 A61K31/427 A61P31/04 

Abstract RU 2754180 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to salt of 1-(((Z)-(1-(2-aminothiazole-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidine-3-yl)methyl)-1-sulfoazetidine-3-yl)amino)ethylidene)amino)oxy)cyclopropancarboxylic acid selected from (L)-arginine salt and sodium salt. The invention also relates to a hydrated solid form of 1-(((Z)-(1-(2-aminothiazole-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidine-3-yl)methyl)-1-sulfoazetidine-3-yl)amino)ethylidene)amino)oxy)cyclopropancarboxylic acid.

EFFECT: compounds, according to the invention, are intended for the use in production of a drug for the treatment of gram-negative bacteria infection.

8 cl, 5 tbl, 14 dwg

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RU 2 754 180 C2

Authors

Aubin, Eric

Casarez, Anthony

Fisch, Andreas

Li, Zaixing

Lindvall, Mika

Moser, Heinz Ernst

Mutz, Michael

Reck, Folkert

Riebesehl, Bernd Ulrich

Schoenhentz, Marc

Sethuraman, Vijay

Simmons, Robert Lowell

Dates

2021-08-30Published

2016-09-20Filed