FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel crystalline polymorph (form II) of 1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, which is characterised by X-ray powder diffraction pattern, including characteristic peaks, expressed by the following values of angle 2-theta ± 0.2: (°2Θ) 17.22, 19.14, 19.23, 20.34, 24.17 and 25.02; or to crystalline polymorph (form II) of 1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, which is characterised by X-ray powder diffraction pattern, which includes characteristic peaks, expressed by the following values of angle 2-theta ± 0.2: (°2Θ) 16.41, 17.09, 17.22, 17.78, 19.14, 19.23, 20.34, 24.17, 24.76, 25.02, 28.88, 26.11, 28.00, 28.52, 28.95, 29.21, 29.99 and 30.82. Invention also relates to salt of 1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, selected from the group, consisting of salts of L-arginine, D-arginine and L-lysine, and to application of said crystalline polymorph and salt for prevention or treatment of Alzheimer's disease.
EFFECT: obtaining salts for prevention or treatment of Alzheimer's disease.
11 cl, 4 dwg, 9 tbl, 2 ex
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