FIELD: biotechnology.
SUBSTANCE: invention relates to an isolated antibody, or its antigen-binding fragment, which binds to a protein, Epsin-1 (EPN1), as well as to a conjugate and a composition containing it. Also disclosed is an isolated nucleic acid molecule encoding a VHC antibody or an antigen-binding fragment thereof, recovered nucleic acid molecule coding VLC antibody or its antigen-binding fragment, as well as vector and cell containing same.
EFFECT: invention is effective for inhibiting growth or dissemination of tumor containing cells expressing EPN1, as well as for treating oncological disease or a hyperplastic disorder containing cells expressing EPN1.
26 cl, 17 dwg, 6 tbl, 7 ex
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