FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, more specifically to therapeutic proteins based on chimeric domains of interleukin-1 (hereinafter – IL-1) family proteins; it can be used in medicine for the treatment of autoimmune disease, inflammatory disease or cancer, as well as for the treatment of an individual suffering from dry eye or allergic conjunctivitis or having a risk of developing the specified pathology. A chimeric protein is constructed based on IL-1beta and IL-1Ra domains.
EFFECT: invention allows for producing protein, which binds to IL-1 receptor I (IL-1RI) and inhibits its activity.
45 cl, 12 dwg, 10 tbl, 10 ex
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