FIELD: biotechnology.
SUBSTANCE: invention relates to production of fused proteins, which are conditionally active versions of interleukin 2 (IL-2) and can be used in medicine for treating tumours. Disclosed is conditionally active IL-2, containing a fused polypeptide, which includes an IL-2 polypeptide, an element for prolonging half-life and an IL-2 blocking fragment connected by linkers.
EFFECT: invention provides obtaining a conditionally active prodrug of IL-2 with an extended half-life, which delivers active IL-2 after cleavage by a protease, in particular, to the desired sites of activity, such as the tumour microenvironment.
10 cl, 23 dwg, 3 tbl, 13 ex
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