AMINOMETHYLPIPERIDINE DERIVATIVES AS KINASE INHIBITOR Russian patent published in 2021 - IPC C07D487/04 A61K31/496 A61K31/519 

Abstract RU 2756505 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by the following chemical formula 1, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein in the chemical formula 1 X1 constitutes N-R1 or S, X2 constitutes CH or N, R1 constitutes ethyl, isobutyl, cyclopropyl, cyclopentyl or 2-((tert-butoxycarbonyl)amino)ethyl, R 2 constitutes hydrogen or halogen, and R 3 constitutes hydrogen or C1-5alkyl. The invention also relates to a specific compound, a pharmacologically acceptable salt or a stereoisomer thereof presented in the claims.

EFFECT: compounds according to the invention are intended for producing a pharmaceutical composition for prevention or treatment of an inflammatory disease, autoimmune disease, proliferative disease, hyperproliferative disease, immunity-mediated disease, cancer or tumour mediated by an inhibitory effect against JAK 3 and BTK kinases.

6 cl, 2 tbl, 12 ex

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RU 2 756 505 C1

Authors

Kim, In Woo

Kim, Nam Youn

Jeong, Seung Hwarn

Kim, Bo-Kyoung

Lee, Jun Hee

Dates

2021-10-01Published

2018-12-28Filed