DERIVATIVES OF OXIFLUOROPIPERIDINE AS A KINASE INHIBITOR Russian patent published in 2021 - IPC C07D487/04 A61K31/519 A61P35/00 A61P37/00 

Abstract RU 2758370 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound represented by the chemical formula 1, or to a pharmaceutically acceptable salt thereof, wherein, in the chemical formula 1, R1 constitutes pyrazolyl, wherein R 1 is substituted by Ra, Ra constitutes C1-5 hydroxyalkyl or piperidinyl, and R2 constitutes hydrogen. The invention also relates to specific compounds represented in the formula, as well as to a pharmaceutical composition exhibiting inhibitory activity against JAK3 and/or BTK, based on the above compounds.

EFFECT: production of new compounds and a pharmaceutical composition based thereon, potentially applicable in medicine for treating inflammatory, autoimmune, proliferative diseases.

[Chemical formula 1]

6 cl, 2 tbl, 36 ex

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RU 2 758 370 C1

Authors

Kim, In Woo

Jun, Sun Ah

Kim, Nam Youn

Lee, Jun Hee

Dates

2021-10-28Published

2018-12-28Filed