FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a compound represented by the chemical formula 1, or to a pharmaceutically acceptable salt thereof, wherein, in the chemical formula 1, R1 constitutes pyrazolyl, wherein R 1 is substituted by Ra, Ra constitutes C1-5 hydroxyalkyl or piperidinyl, and R2 constitutes hydrogen. The invention also relates to specific compounds represented in the formula, as well as to a pharmaceutical composition exhibiting inhibitory activity against JAK3 and/or BTK, based on the above compounds.
EFFECT: production of new compounds and a pharmaceutical composition based thereon, potentially applicable in medicine for treating inflammatory, autoimmune, proliferative diseases.
[Chemical formula 1]
6 cl, 2 tbl, 36 ex
Title | Year | Author | Number |
---|---|---|---|
DERIVATIVES OF AMINOFLUORPIPERIDINE AS A KINASE INHIBITOR | 2018 |
|
RU2762637C1 |
PYRAZOLOPYRIMIDINE DERIVATIVES AS A KINASE INHIBITOR | 2017 |
|
RU2714206C1 |
AMINOMETHYLPIPERIDINE DERIVATIVES AS KINASE INHIBITOR | 2018 |
|
RU2756505C1 |
PYRROLOTRIAZINE DERIVATIVES AS KINASE INHIBITOR | 2018 |
|
RU2726632C1 |
SUBSTITUTED CARBONUCLEOSIDES DERIVATIVES USED AS ANTICANCER AGENTS | 2017 |
|
RU2712944C1 |
NEW PYRROLOPYRIMIDINE COMPOUND OR ITS SALT, PHARMACEUTICAL COMPOSITION CONTAINING IT, IN PARTICULAR, AGENT FOR PREVENTION AND / OR TREATMENT OF TUMORS AND SO ON, BASED ON INHIBITING INFLUENCE ON NAE | 2015 |
|
RU2658008C2 |
ANTITUMOUR EFFECT ENHANCER CONTAINING PYRROLOPYRIMIDINE COMPOUND | 2016 |
|
RU2710380C1 |
3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF | 2013 |
|
RU2576384C1 |
INFLUENZA VIRUS REPLICATION INHIBITORS, METHODS OF APPLICATION AND USING | 2016 |
|
RU2737190C2 |
ANTITUMOR DRUG FOR INTERMITTENT ADMINISTRATION OF FGFR INHIBITOR | 2014 |
|
RU2664118C2 |
Authors
Dates
2021-10-28—Published
2018-12-28—Filed