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2 759 054

(13)

(51)

IPC

A61K39/145(2006-01-01)

C12N7/04(2006-01-01)

(21) (22)

Application

2019138497, 2019-11-27

(24)

Start date

2019-11-27

(22)

Actual filing date

2019-11-27

(45)

Published

2021-11-09

(72)

Inventor

Stukova Marina AnatolevnaSergeeva Mariya ValerevnaRomanovskaya-Romanko Ekaterina AndreevnaPulkina Anastasiya AleksandrovnaEgorov Andrej Yurevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Institut Grippa Imeni A.A. Smorodintseva" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Grippa Im. A.A. Smorodintseva" Minzdrava Rossii)

RECOMBINANT STRAIN OF A/PR8-NS124-Luc INFLUENZA VIRUS AND METHOD FOR EVALUATING POST-VACCINAL NEUTRALIZING ANTIBODIES USING BIOLUMINESCENT DETECTION Russian patent published in 2021 - IPC A61K39/145 C12N7/04

Abstract RU 2759054 C2

FIELD: biotechnology; virology; medicine.

SUBSTANCE: recombinant virus of A/PR8-NS124-Luc influenza, Orthomyxoviridae family, Influenza virus A genus, H1N1 subtype expressing NanoLuc protein as part of open reading frame of shortened NS1 protein deposited in the State virus collection under No.2906 is described. A method for quick evaluation of neutralizing activity of antibodies in RDE processed blood serum using a recombinant influenza virus A expressing NanoLuc protein as part of open reading frame of shortened NS1 protein is presented.

EFFECT: invention allows for detection of the development of influenza infection in living biological systems and quick evaluation of neutralizing activity of antibodies and antiviral activity of chemical preparations.

5 cl, 10 dwg, 3 tbl, 6 ex

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RU 2 759 054 C2

Authors

Stukova Marina Anatolevna

Sergeeva Mariya Valerevna

Romanovskaya-Romanko Ekaterina Andreevna

Pulkina Anastasiya Aleksandrovna

Egorov Andrej Yurevich

Dates

2021-11-09—Published

2019-11-27—Filed