FIELD: biotechnology; virology; medicine.
SUBSTANCE: recombinant virus of A/PR8-NS124-Luc influenza, Orthomyxoviridae family, Influenza virus A genus, H1N1 subtype expressing NanoLuc protein as part of open reading frame of shortened NS1 protein deposited in the State virus collection under No.2906 is described. A method for quick evaluation of neutralizing activity of antibodies in RDE processed blood serum using a recombinant influenza virus A expressing NanoLuc protein as part of open reading frame of shortened NS1 protein is presented.
EFFECT: invention allows for detection of the development of influenza infection in living biological systems and quick evaluation of neutralizing activity of antibodies and antiviral activity of chemical preparations.
5 cl, 10 dwg, 3 tbl, 6 ex
| Title |
Year |
Author |
Number |
| RECOMBINANT STRAIN OF INFLUENZA VIRUS A/PR8-NS124-TB10_4-2A-HSPX AND METHOD FOR SPECIFIC PREVENTION OF PULMONARY TUBERCULOSIS USING MUCOSAL VACCINE BASED THEREON |
2019 |
- Stukova Marina Anatolevna
- Vinogradova Tatyana Ivanovna
- Zabolotnykh Nataliya Vyacheslavovna
- Sergeeva Mariya Valerevna
- Buzitskaya Zhanna Valerevna
|
RU2726106C1 |
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2018 |
- Pulkina Anastasiya Aleksandrovna
- Sergeeva Mariya Valerevna
- Tsybalova Lyudmila Markovna
- Stukova Marina Anatolevna
|
RU2678175C1 |
| RECOMBINANT INFLUENZA VIRUS INTENDED FOR THE PREVENTION OF COVID-19 AND INFLUENZA, METHOD OF ITS PRODUCTION AND USE |
2022 |
- Sergeeva Mariya Valerevna
- Elshin Nikita Dmitrievich
- Romanovskaya-Romanko Ekaterina Andreevna
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- Lioznov Dmitrij Anatolevich
|
RU2802058C1 |
| INFLUENZA VIRUS STRAIN A/Hongkong/1/68/162/35 (H3N2) - UNIVERSAL DONOR OF INTERNAL GENES FOR REASSORTANTS, AND REASSORTANT STRAINS A/SPB/GK/09 (H1N1) AND A/HK/Astana/6:2/2010 (H5N1) PREPARED THEREOF |
2011 |
- Tsybalova Ljudmila Markovna
- Gorev Nikolaj Efremovich
- Repko Irina Anatol'Evna
- Potapchuk Marina Valentinovna
- Sergeeva Marija Valer'Evna
- Kiselev Oleg Ivanovich
|
RU2511431C2 |
| RECOMBINANT VACCINE STRAIN FOR LIVE INTRANASAL VACCINE PROVIDING COMBINED PREVENTION OF INFLUENZA AND CORONAVIRUS INFECTIONS |
2022 |
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- Stepanova Ekaterina Alekseevna
- Mezhenskaya Darya Andreevna
- Matyushenko Viktoriya Arkadevna
- Rudenko Larisa Georgievna
|
RU2782531C1 |
| RECOMBINANT INFLUENZA VIRUS STRAINS EXPRESSING MYCOBACTERIAL PROTECTIVE ESAT-6 ANTIGEN AND USES THEREOF IN TUBERCULOSIS TREATMENT AND PROPHYLAXIS |
2005 |
- Egorov Andrej Jur'Evich
- Kiselev Oleg Ivanovich
- Stukova Marina Anatol'Evna
- German Katinger
|
RU2318872C2 |
| RECOMBINANT VIRUS-LIKE PARTICLES (VLP) USING BOVINE IMMUNODEFICIENCY VIRUS GROUP-SPECIFIC ANTIGEN (GAG) PROTEIN |
2016 |
- Pushko Piter
- Tretyakova Irina
|
RU2734118C2 |
| ATTENUATED INFLUENZA VECTORS FOR THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASES, AS WELL AS FOR CANCER TREATMENT |
2015 |
- Egorov Andrej Yurevich
- Ferko Boris
- Krokhin Artem Aleksandrovich
- Romanova Yuliya Romanovna
|
RU2628690C2 |
| CHIMERIC INFLUENZA VACCINES |
2021 |
- Wong, Chi-Huey
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- Wang, Shih-Chi
- Ko, Yi-An
- Lin, Kuo-I
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- Cheng, Ting-Jen
|
RU2834969C1 |
| VERSIONS OF HAEMAGGLUTININS OF SWINE FLU VIRUS |
2010 |
|
RU2560420C2 |
