ANTI-INFLAMMATORY COMPOUND, PRODUCTION AND APPLICATION THEREOF Russian patent published in 2021 - IPC C07D401/04 C07D405/12 C07D409/12 C07D213/68 A61K31/4412 A61P17/00 A61P29/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to the field of pharmaceutical chemistry, in particular, to an anti-inflammatory compound with the structure (I), wherein R^A constitutes hydrogen, an alkyl containing 1 to 6 carbon atoms, and one or several hydrogen atoms in the above groups, attached to the carbon in said groups, are optionally substituted with an alkyl containing 1 to 6 carbon atoms, a cycloalkyl constituting a three-membered, four-membered, five-membered, or six-membered cycle, or a halogen; R^B constitutes hydrogen, an alkyl containing 1 to 6 carbon atoms, a cycloalkyl constituting a three-membered, four-membered, five-membered, or six-membered cycle, a heterocycloalkyl constituting an oxo/thio three-membered, four-membered, five-membered, or six-membered cycle, an alkenyl containing 2 to 4 carbon atoms, or alkynyl containing 2 to 4 carbon atoms, and one or several hydrogen atoms in the above groups, attached to the carbon in said groups, are optionally substituted with an alkyl containing 1 to 6 carbon atoms, a cycloalkyl constituting a three-membered, four-membered, five-membered, or six-membered cycle, or a halogen, and one or several carbon atoms in said groups are optionally substituted with sulphur, a sulphur atom, sulphoxide, sulphone or sulphonyl; R^C constitutes hydrogen; R^D1 constitutes hydrogen, oxygen, hydroxy, cyano, alkyl containing 1 to 6 carbon atoms, phenyl, an ester group, carboxyl, or alkynyl containing 2 to 4 carbon atoms, and one or several hydrogen atoms in the above groups, attached to the carbon/oxygen in said groups, are optionally substituted with an alkyl containing 1 to 6 carbon atoms, a cycloalkyl constituting a three-membered, four-membered, five-membered, or six-membered cycle, an alkynyl containing 2 to 4 carbon atoms, an alkenyl containing 2 to 4 carbon atoms, or a phenyl, and one or several carbon atoms in said groups are optionally substituted with a sulphur atom; the C₁-R^D1 bond constitutes a single or double bond; R^D2 constitutes hydrogen or a cyano; G1 constitutes a single bond, a double bond or a cyclopropane containing C₁ and C₂; and R^E constitutes an alkyl containing 1 to 6 carbon atoms, or a halogen. Also described are methods for producing the above compounds are described, as well as an application thereof for treatment of skin diseases associated with PDE4, and a medicinal product for treatment of inflammatory skin diseases, based on compounds by the formula (I).

EFFECT: produced and described compounds with a strong inhibitory effect on PDE4, capable of easily permeating the skin and being used in treatment of inflammatory skin diseases.

20 cl, 1 tbl, 123 ex