DRUG EFFECTIVE FOR LYMPHOGENIC METHOD FOR THE INJECTION OF DRUG Russian patent published in 2021 - IPC A61K31/337 A61K31/4745 A61K31/513 A61K45/00 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a cancer treatment agent intended for the injection into a lymph node. A pharmaceutical composition for the treatment of cancer intended for the injection into a lymph node is proposed, containing at least one anticancer drug selected from a group consisting of 5-fluorouracil, irinotecan, docetaxel and their salts with pharmaceutically acceptable inorganic acids or organic acids as an active ingredient, where the amount of 5-fluorouracil or its salt in the composition is from 1 ng to 100 mg, the amount of irinotecan or its salt and/or docetaxel or its salt in the composition is from 1 ng to 20 mg, and the pharmaceutical composition has a viscosity of 1-10 MPa⋅s. The use of at least one anticancer drug selected from a group consisting of 5-fluorouracil, irinotecan, docetaxel and their salts with pharmaceutically acceptable inorganic acids or organic acids is proposed in the preparation of a pharmaceutical composition for the treatment of cancer intended for the injection into a lymph node, where the amount of 5-fluorouracil or its salt in the composition is from 1 ng to 100 mg, the amount of irinotecan or its salt and/or docetaxel or its salt in the composition is from 1 ng to 20 mg, and the pharmaceutical composition has a viscosity of 1-10 MPa⋅s. The use of a pharmaceutical composition containing at least one anticancer drug selected from a group consisting of 5-fluorouracil, irinotecan, docetaxel and their salts with pharmaceutically acceptable inorganic acids or organic acids is proposed for the treatment of cancer by the injection into a lymph node, where the amount of 5-fluorouracil or its salt in the composition is from 1 ng to 100 mg, the amount of irinotecan or its salt and/or docetaxel or its salt in the composition is from 1 ng to 20 mg, and the pharmaceutical composition has a viscosity of 1-10 MPa⋅s. A method for the treatment of cancer is proposed, including the injection into a patient’s lymph node of a pharmaceutical composition that contains at least one anticancer drug selected from a group consisting of 5-fluorouracil, irinotecan, docetaxel and their salts with pharmaceutically acceptable inorganic acids or organic acids, where the amount of 5-fluorouracil or its salt in the composition is from 1 ng to 100 mg, the amount of irinotecan or its salt and/or docetaxel or its salt in the composition is from 1 ng to 20 mg, and the pharmaceutical composition has a viscosity of 1-10 MPa⋅s.

EFFECT: above-described drugs are effective for the treatment of cancer when a pharmaceutical composition is injected into the patient’s lymph node, they provide tumor regression by 90% or more, when using a small dose of the drug.

5 cl, 4 dwg, 7 tbl, 4 ex