METHOD FOR DIFFERENTIATING CAUSES OF DEVELOPMENT OF INITIAL STAGE OF HEPATIC FIBROSIS IN CHRONIC VIRAL HEPATITIDES B AND C Russian patent published in 2021 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular, to methods for laboratory diagnostics of hepatic diseases, and can find an application in specifying the cause of hepatic fibrosis in clinical and laboratory conditions. The problem solved herein is the creation of a method for determining the causes of development of hepatic fibrosis which makes it possible to reduce the amount of measured indicators, simultaneously increasing sensitivity and maintaining the required specificity. Use of the CCL2/MCP-1, CCL8/MCP-2, IFNγ cytokines as determined protein products is proposed. Concentration thereof is determined in blood plasma, and the cause of hepatic fibrosis is diagnosed by the correspondence of the concentration of the marker to the threshold values. The following threshold values for differential diagnostics of chronic hepatitis B and chronic hepatitis C have been obtained as a result of the analysis: CCL2/MCP-1 - 245.3 pg/ml, CCL8/MCP-2 - 21.5 and 28.0 pg/ml, IFNγ - 2.5 pg/ml.

EFFECT: use of the algorithm for diagnosing the stages of hepatic fibrosis makes it possible to achieve a sensitivity of the method of 83.3 to 86.2% with sufficient specificity.

1 cl, 1 dwg, 2 ex