METHOD OF PREDICTING AN INCREASED RISK OF DECOMPENSATION OF LIVER CIRRHOSIS OR THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH LIVER CIRRHOSIS IN THE OUTCOME OF CHRONIC HEPATITIS C AFTER ACHIEVING A SUSTAINED VIROLOGIC RESPONSE Russian patent published in 2023 - IPC A61B8/08 A61B8/13 G01N33/48 

FIELD: medicine, therapy.

SUBSTANCE: invention can be used to predict an increased risk of decompensation of liver cirrhosis or the development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis in the outcome of chronic hepatitis C after achieving a sustained virological response (SVR). The indices MELD (Model for End-Stage Liver Disease), FIB-4 (The Fibrosis-4 Index) are calculated. Liver elastometry is performed. Points are assigned to the values of the MELD, FIB-4 indices and the value of liver density: if the MELD value is more than or equal to 10 at the start of antiviral therapy (HTP), 2 points are assigned, if the liver density value is more than or equal to 30 kPa at the start of HTP, 1 point is assigned, if the value of FIB-4 is greater than or equal to 3.25 at SVR point, 1 point is assigned. If the sum of points for all indicators is at least two, an increased risk of decompensation of liver cirrhosis or the development of HCC is predicted.

EFFECT: invention makes it possible to identify groups of patients who need more frequent and longer examinations after therapy, and the possibility to adjust the duration of dispensary observation of patients in the future after treatment with a reduction in the observation period for patients with a low risk of developing decompensation of cirrhosis and the development of HCC.

1 cl, 1 dwg, 3 ex