COUMARIN DERIVATIVE FOR TREATMENT OR PREVENTION OF CELL PROLIFERATION DISORDERS Russian patent published in 2021 - IPC A61K31/37 A61K31/573 A61P35/04 A61P35/00 

Abstract RU 2760006 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method for treatment or prevention of cell proliferation disorders in KRAS-mutant and/or NRAS-mutant cancer, including (a) administering a potassium salt of the compound represented by the formula (I) twice a week for 3 weeks in a dose of 3.2 or 4 mg per administration, (b) suspending administration of said salt for the next 1 week, and (c) consecutively repeating the stages (a) and (b) at least once.

EFFECT: described method provides a possibility of reducing the side effects in the form of a rash in patients receiving a medicinal product containing a compound by the formula (I).

14 cl, 1 dwg, 2 ex

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RU 2 760 006 C1

Authors

Banerji, Udai

Dates

2021-11-22Published

2017-11-16Filed