FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a bispecific antigen-binding molecule binding to OX40 and FAP, which contains at least one Fab-fragment having the capability of specific binding to OX40, and at least one fragment having the capability of specific binding to a fibroblast-activating protein (FAP), as well as to a composition containing it. Polynucleotide encoding the above-mentioned molecule is also disclosed.
EFFECT: invention is effective for stimulating T-cell response.
11 cl, 44 dwg, 73 tbl, 11 ex
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