BISPECIFIC ANTIBODIES SPECIFIC RELATIVELY TO COSTIMULATORY TNF-RECEPTOR Russian patent published in 2021 - IPC C07K16/28 C07K16/30 C07K16/40 A61K39/395 A61P35/00 A61P43/00 

Abstract RU 2761115 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a bispecific antigen-binding molecule binding to OX40 and FAP, which contains at least one Fab-fragment having the capability of specific binding to OX40, and at least one fragment having the capability of specific binding to a fibroblast-activating protein (FAP), as well as to a composition containing it. Polynucleotide encoding the above-mentioned molecule is also disclosed.

EFFECT: invention is effective for stimulating T-cell response.

11 cl, 44 dwg, 73 tbl, 11 ex

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RU 2 761 115 C1

Authors

Amann Mariya

Bryunker Peter

Klaus Kristina

Ferrara Koller Klaudiya

Grau-Richards Sandra

Khosse Ralf

Klyajn Kristian

Levitski Viktor

Umana Pablo

Dates

2021-12-06Published

2016-09-29Filed