T-CELL RECEPTORS RECOGNIZING R175H OR Y220C MUTATION IN p53 Russian patent published in 2024 - IPC C07K14/725 A61K35/17 G01N33/574 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to production of T-cell receptors (TCR), which recognize mutant p53 protein and can be used in medicine to detect and treat cancer, which expresses the amino acid sequence of the human p53^Y220C, presented by molecule HLA-A*02:01. Disclosed is a TCR having antigen specificity with respect to the amino acid sequence of a human p53^Y220C, presented by a molecule of human leukocyte antigen (HLA)-A* 2:01. Also disclosed are agents and methods for recombinant production of TCR and for use in therapy and diagnostics.

EFFECT: invention provides obtaining TCR for expression by cells used for adaptive transfer of cells, which are mainly aimed at destruction of cancer cells while minimizing or eliminating the destruction of normal, non-cancerous cells, thereby reducing side effects by minimizing or eliminating toxicity.

39 cl, 13 dwg, 12 tbl, 12 ex