FIELD: medicine.
SUBSTANCE: invention relates to new conjugates of a binder and active substance (hereinafter – ADC) with improved properties, active metabolites of these ADC, as well as to a method for their preparation. In addition, the present invention relates to the use of these conjugates for the treatment and/or prevention of diseases, as well as to the use of these conjugates for the preparation of drugs for the treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases, such as, for example, cancer.
EFFECT: obtaining conjugates for the treatment of hyperproliferative an/or angiogenic diseases.
31 cl, 2 dwg, 7 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-CEACAM6 ANTIBODIES AND USE THEREOF | 2016 |
|
RU2739163C2 |
| NEW ANTIBODIES AGAINST XI FACTOR AND THEIR APPLICATIONS | 2017 |
|
RU2758160C2 |
| MONOVALENT ANTIBODIES TO PROPERDIN AND FRAGMENTS OF ANTIBODIES | 2018 |
|
RU2790103C2 |
| ATRIAL NATRIURETIC PEPTIDE GRAFTED ANTIBODIES | 2019 |
|
RU2822433C2 |
| ANTI-PCSK9 ANTIBODY, ITS ANTIGEN-BINDING DOMAIN AND MEDICAL APPLICATION THEREOF | 2016 |
|
RU2739208C2 |
| ANTI-CEACAM1 ANTIBODY AND ITS APPLICATION | 2018 |
|
RU2754876C2 |
| ANTIBODIES DIRECTED AGAINST Fc-RECEPTOR-LIKE PROTEIN 5 AND METHODS FOR THEIR APPLICATION | 2016 |
|
RU2774158C2 |
| ANTI-IL31 ANTIBODIES FOR VETERINARY USE | 2018 |
|
RU2795485C2 |
| ANTI-PD-1 ANTIBODIES | 2019 |
|
RU2788095C2 |
| CD40L ANTIBODIES AND METHODS OF TREATING CD40L RELATED DISEASES AND DISORDERS | 2016 |
|
RU2727646C2 |
