ATRIAL NATRIURETIC PEPTIDE GRAFTED ANTIBODIES Russian patent published in 2024 - IPC C07K16/00 C07K14/58 C07K19/00 C12N15/62 C12N15/63 A61K38/22 A61K39/395 A61P9/12 

FIELD: biotechnology.

SUBSTANCE: disclosed are antibodies or fragments thereof suitable as a natriuretic peptide receptor agonist. Antibodies or fragments thereof contain a heterologous amino acid sequence within a CDR portion, wherein said heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), an atrial natriuretic peptide (ANP) and a C-terminal linker sequence (Ctls). Invention also relates to the use of an antibody or a fragment thereof in a method of treating, a composition comprising the antibody or a fragment thereof, a nucleic acid or a mixture of nucleic acids encoding the antibody or fragment thereof, a host cell containing such a nucleic acid or such a mixture of nucleic acids, as well as a method of producing an antibody or a fragment thereof.

EFFECT: invention provides obtaining agonists of the natriuretic peptide receptor with increased stability in serum as compared to wild-type natriuretic peptides of natural origin.

12 cl, 17 dwg, 11 tbl, 12 ex