HUMANIZED ANTIBODIES SPECIFIC TO ALPHA-ENOLASE AND METHODS FOR USE IN ANTITUMOR THERAPY Russian patent published in 2021 - IPC C07K16/40 C12N5/10 C12N15/13 C12N15/63 A61K39/395 A61P35/00 

Abstract RU 2761662 C2

FIELD: biotechnology.

SUBSTANCE: present invention relates to the field of biotechnology, in particular to a new humanized antibody; it can be used in medicine. The invention discloses an antibody capable of binding to a human alpha-enolase (ENO1) protein, which can be used in the medical practice in the therapy of a number of tumor diseases, cells of which express ENO1 protein on the surface in the form of a plasminogen receptor.

EFFECT: obtaining antibodies for the antitumor therapy.

11 cl, 13 dwg, 2 tbl, 13 ex

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RU 2 761 662 C2

Authors

Chen, Li-Tzong

Liu, Ko-Jiunn

Shih, Neng-Yao

Wu, Chung-Hsiun

Lok, Ying-Yung

Tsai, Ya-Wei

Huang, Chao-Yang

Wu, Chia-Cheng

Lai, Jiann-Shiun

Tseng, Shih-Chi

Yuan, Ta-Tung

Tsai, Shih-Chong

Dates

2021-12-13Published

2014-12-31Filed