DOSE AND INJECTION MODE FOR INHIBITORS OF INTERACTION OF HDM2 WITH P53 Russian patent published in 2021 - IPC A61K31/496 A61K31/506 A61K31/401 A61K31/404 A61K31/4418 A61K31/4439 A61K31/47 A61P35/00 

Abstract RU 2762573 C2

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment of cancer with TP54 of a wild type, including the injection of HDM201 in two different injection days within a treatment cycle, where the first injection day and the second injection day are separated by a short period without injection, and the second injection day of the first or earlier treatment cycle and the first injection of the following cycle are separated by an extended period without the injection, where the short period without the injection consists of 4-8 days, and the extended period without the injection consists of 13-27 days, and where the treatment consists of at least 2 treatment cycles, while the daily dose in injection days is from 100 to 200 mg.

EFFECT: claimed method allows for the injection of a high dose providing the efficiency and the reduction in the risk of undesired occurrences.

9 cl, 8 dwg, 17 tbl, 5 ex

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RU 2 762 573 C2

Authors

Ferretti, Stephane

Guerreiro, Nelson

Jeay, Sebastien

Jullion, Astrid

Meille, Christophe

Wuerthner, Jens

Dates

2021-12-21Published

2017-11-14Filed