METHODS FOR TREATMENT OF DISORDERS OF CIRCADIAN SLEEP RHYTHM Russian patent published in 2021 - IPC A61K31/506 A61P43/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the field of pharmaceutics, namely to methods for the treatment of an irregular sleep-wake rhythm, associated increased sleepiness and/or daytime drowsiness, a disorder of a circadian sleep rhythm due to Alzheimer’s disease, selected from sleep interruption, sleep-wake fragmentation and irregular sleep-wake rhythm, to methods for the improvement of nighttime sleep continuity, behavioral and cognitive problems in a subject with an irregular sleep-wake rhythm, with dementia due to Alzheimer’s disease, with mild cognitive impairment due to Alzheimer’s disease, to methods for the stabilization and improvement of one or several circadian rhythms in a subject. Methods include the injection of the effective amount of at least one compound selected from ((1R,2S)-2-(((2,4-dimethylpyrimidine-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropancarboxamide, its pharmaceutically acceptable salts and solvates, once a day every day before sleep or once a day every other day before sleep.

EFFECT: group of inventions provides for the creation of safe and effective therapy that is easy for the injection for the treatment of sleep-wake fragmentation in patients with an irregular sleep-wake rhythm.

42 cl, 2 dwg, 2 tbl, 5 ex