HETEROCYCLIC COMPOUND AS INHIBITOR OF CASEIN KINASE 1δ AND/OR ACTIVIN RECEPTOR-LIKE KINASE 5 Russian patent published in 2023 - IPC C07D405/14 A61K31/4439 A61P25/20 A61P25/28 A61P27/02 A61P35/00 A61P43/00 

FIELD: pharmaceuticals.

SUBSTANCE: compound represented by formula (1), or a pharmaceutically acceptable salt thereof. In formula (1): R¹, R⁴ and R⁵ are hydrogen, R⁶, R⁷, R⁹ and R¹⁰ are each independently hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, R⁸ is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl or halogen, where R² and R³ or R⁴ and R⁵ together with the two carbon atoms to which they are attached form a tetrahydrofuran ring having the following structure:

wherein the carbon atoms with an asterisk (*) represent carbon atoms of the benzene ring bonded to R² and R³, where the tetrahydrofuran ring is optionally substituted with C1-C6 alkyl. Also the following is proposed: a casein kinase 1 inhibitorδ and activin receptor-like kinase 5 (ALK5), including the specified compound, therapeutic medicinal products containing the specified compound.

EFFECT: proposed compound has inhibitory activity against CK1δ and/or inhibitory activity against ALK5 and can be used for the treatment of circadian rhythm sleep disorders, for the treatment of dementia of the Alzheimer's type, for the treatment of cancer, for the treatment of corneal dystrophy, and for the treatment of androgenetic alopecia.

13 cl, 6 tbl, 17 ex