HISTONES AND/OR proADM AS MARKERS TESTIFYING ABOUT ORGAN DYSFUNCTION Russian patent published in 2022 - IPC G01N33/68 G01N33/74 

FIELD: diagnostics.

SUBSTANCE: group of inventions relates to the diagnostics of organ dysfunction in a subject. A method for the diagnostics of multiorgan dysfunction in a subject is disclosed, wherein the specified method includes (i) determination of a level of at least one histone in a sample from the specified subject; (i1) comparison of the specified level of at least one histone with the control level of this at least one histone; (ii) determination of a level of proadrenomedullin (hereinafter – proADM) in a sample from the specified subject; and (ii1) comparison of the specified proADM level with the control proADM level; (iii) multiorgan dysfunction is diagnosed in the specified subject based on the comparison at the stage (i1) and (ii1), respectively. A kit for the implementation of the specified method and the use of the specified kit are also disclosed.

EFFECT: group of inventions provides for the improved diagnostics of organ dysfunction due to the use of two markers in comparison with the determination of only one marker.

15 cl, 6 dwg, 5 tbl, 1 ex