FIELD: medicine.
SUBSTANCE: presented group of inventions refers to medicine, namely to paediatrics. Disclosed is a method for diagnosing renal dysfunction in a child, involving determining the level of proenkephalin or fragments thereof, selected from a group comprising SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 5, SEQ ID No. 6, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 and SEQ ID No. 11, in body fluid, and correlating said level of proenkephalin or its fragments with renal dysfunction, where an increased level above the threshold, which is in range of 150–1290 pmol/l, is a diagnostic sign of kidney dysfunction in a child. Disclosed is use of a kit for implementing said method, wherein said kit contains at least two antibodies or antibody fragments directed to amino acids 133–140 (LKELLETG, SEQ ID No. 13) and amino acids 152–159 (SDNEEEVS, SEQ ID No. 14).
EFFECT: presented group of inventions provides effective diagnosis of renal dysfunction in children by determining the level of proenkephalin or its fragments in body fluid.
12 cl, 6 dwg, 7 tbl, 3 ex
