BICYCLIC AMINES AS NEW INHIBITORS OF JAK KINASE Russian patent published in 2022 - IPC C07D471/04 C07D487/04 C07D519/00 A61K31/519 A61P37/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound corresponding to the general formula I

, wherein R₁ represents methyl or ethyl, n equals 1 or 2, R₂ is selected from the group consisting of hydrogen, cyano, –SO₂R_a, –SO₂NR_bR_c, –C(O)R_b, phenyl, and 5– and 6–membered heteroaryl, wherein said phenyl, 5– and 6–membered heteroaryl comprises 1 to 3 heteroatoms selected from S and N, and wherein said 5– and 6–membered heteroaryl is optionally substituted by one or more substituents independently selected from R₃, R₃ represents a group consisting of cyano, halogen, (C₁–C₄)alkyl, hydroxy(C₁–C₄)alkyl, (C₁–C₄)alkoxy, –SO₂R_a, and –SO₂NR_bR_c, R_a is selected from (C₁–C₄)alkyl and halogen(C₁–C₄)alkyl, R_b and R_c are each independently selected from hydrogen, (C₁–C₄)alkyl, cyano(C₁–C₄)alkyl and cyano(C₃–C₆)cycloalkyl or a pharmaceutically acceptable salt thereof. Also proposed are a pharmaceutical composition and a method for preventing, treating, or alleviating psoriasis and atopic dermatitis.

EFFECT: production of new organic compounds - inhibitors of protein tyrosine kinases, such as JAK kinases.

17 cl, 1 dwg, 3 tbl, 47 ex