FIELD: cellular biology.
SUBSTANCE: present invention relates to cellular biology, in particular to an isolated population of Treg CD8+CD45RClow cells secreting IFNγ+IL-10+IL-34+, a pharmaceutical composition for the prevention or treatment of graft rejection, GVH (graft versus host) reaction, chronical inflammatory diseases, autoimmune diseases, undesired immune response against therapeutic proteins or allergies, as well as to methods for detecting, isolating and reproducing Treg CD8+CD45RClow cells secreting IFNγ+IL-10+IL-34+, use of the specified population for the prevention or treatment, and a method for determining the risk of the specified diseases.
EFFECT: present invention discloses new subpopulation of Treg CD8+CD45RClow cells.
13 cl, 15 dwg, 1 ex
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