FIELD: biotechnology, immunology and microbiology.
SUBSTANCE: inventions group relates to biotechnology, immunology and microbiology. An expression vector based on an adeno-associated virus with an embedded genetic construct containing the nucleotide sequence SEQ ID NO:2 encoding a recombinant antibody SEQ ID NO:1 was created, and the use of this vector for the prevention of intoxication caused by botulinum neurotoxin type A was proposed.
EFFECT: inventions group provides the creation of a recombinant viral vector that has a lower inflammatory potential and a longer time interval of protective activity.
6 cl, 9 dwg, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SINGLE-DOMAIN ANTIBODY AND ITS MODIFICATIONS SPECIFICALLY BINDING TO BOTULINUM NEUROTOXIN TYPE A, AND METHOD OF USING THEM FOR THERAPY OR EMERGENCY PREVENTION OF INTOXICATION CAUSED BY BOTULINUM NEUROTOXIN TYPE A | 2021 |
|
RU2766348C1 |
| FUSED PROTEIN OF SHORT FORM OF CONE VIABILITY FACTOR OBTAINED FROM RODS, AND HYDROPHILIC PEPTIDE | 2017 |
|
RU2773368C2 |
| CODON-OPTIMIZED NUCLEIC ACID WHICH ENCODES SMN1 PROTEIN, AND USE THEREOF | 2020 |
|
RU2742837C1 |
| RECOMBINANT VIRAL VECTORS WITH MODIFIED TROPISM AND WAYS OF THEIR USE FOR TARGETED INTRODUCTION OF GENETIC MATERIAL INTO HUMAN CELLS | 2018 |
|
RU2809246C2 |
| ISOLATED MODIFIED VPI CAPSID PROTEIN OF ADENO-ASSOCIATED VIRUS OF SEROTYPE 9 (AAV9), CAPSID AND VECTOR BASED THEREON | 2021 |
|
RU2825667C2 |
| COMPOSITION FOR RELIEVING OR TREATING PAIN | 2017 |
|
RU2725830C1 |
| ISOLATED MODIFIED VP1 CAPSID PROTEIN OF ADENO-ASSOCIATED VIRUS OF SEROTYPE 5 (AAV5), CAPSID AND VECTOR BASED ON IT | 2019 |
|
RU2751592C2 |
| ANTIBODY AGAINST B7-H3, ITS ANTIGEN-BINDING FRAGMENT AND THEIR MEDICAL USE | 2018 |
|
RU2765306C2 |
| CODON-OPTIMIZED EXPRESSION CASSETTES OF ACID α-GLUCOSIDASE AND METHODS OF USE THEREOF | 2019 |
|
RU2823353C2 |
| GENE THERAPY FOR THE TREATMENT OF HEMOPHILIA A | 2017 |
|
RU2762257C2 |
