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(19)

(11)

2 726 206

(13)

(51)

IPC

C07D405/14(2006-01-01)

C07D405/04(2006-01-01)

C07D413/14(2006-01-01)

C07D409/12(2006-01-01)

A61K31/536(2006-01-01)

A61K31/453(2006-01-01)

A61K31/496(2006-01-01)

A61K31/4545(2006-01-01)

A61K31/4725(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2017144651, 2016-05-19

(24)

Start date

2016-05-19

(22)

Actual filing date

2016-05-19

(45)

Published

2020-07-09

(72)

Inventor

Fan, JunfaKalisiak, JaroslawLui, Rebecca, M.Mali, Venkat, ReddyMcmahon, Jeffrey, P.Powers, Jay, P.Tanaka, HirokoZeng, YibinZhang, Penglie

(73)

Holder

Chemocentryx, Inc.

MODULATORS CCR2 Russian patent published in 2020 - IPC C07D405/14 C07D405/04 C07D413/14 C07D409/12 A61K31/536 A61K31/453 A61K31/496 A61K31/4545 A61K31/4725 A61P35/00 A61P37/00

Abstract RU 2726206 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention describes compounds of general formula (I) or their pharmaceutically acceptable salts which are modulators of the CCR2 receptor.

(I).

EFFECT: they can be used in pharmaceutical compositions for treating a CCR2-mediated disease or disorder, in methods of treating a mammal suffering from or prone to disease or disorder, selected from the group consisting of renal fibrosis, polycystic kidney disease, rheumatoid arthritis, atopic dermatitis, psoriasis, nephropathy, pancreatic cancer and non-alcoholic steatohepatitis (NS), as well as methods of inhibiting CCR2 receptor-mediated cell chemotaxis, involving contacting mammalian white blood cells with a modulating CCR2 receptor.

52 cl, 2 dwg, 29 ex

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RU 2 726 206 C2

Authors

Fan, Junfa

Kalisiak, Jaroslaw

Lui, Rebecca, M.

Mali, Venkat, Reddy

Mcmahon, Jeffrey, P.

Powers, Jay, P.

Tanaka, Hiroko

Zeng, Yibin

Zhang, Penglie

Dates

2020-07-09—Published

2016-05-19—Filed