SUBSTITUTED IMIDAZOQUINOLINES Russian patent published in 2022 - IPC C07D471/04 A61K31/4745 A61P35/00

Abstract RU 2768629 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of the general formula (I) or its pharmaceutically acceptable salts that can be used as agonists of a toll-like receptor TLR7. In the formula (I), (i) R1 is selected from a group consisting of C_1-6alkyl, C_1-3alkoxy-C_1-3alkyl and C_1-3alkylamino-C_1-3alkyl; R2 is selected from -CONH₂; R3 is tetrahydropyran-4-yl, and n is an integer from 3 to 6; or (ii) R1 is selected from a group consisting of C_1-3alkoxy-C_1-3alkyl or C_1-3alkylamino-C_1-3alkyl; R2 is selected from -CO-R5; R3 is tetrahydropyran-4-yl; n is an integer from 3 to 6, and R5 is selected from C_1-6alkyl. The invention also relates to specific compounds, a pharmaceutical composition for inducing the production of interferon-alpha (IFN-α) containing proposed compounds, a method for the treatment of cancer, and their use for the production of a drug for the treatment of cancer.

EFFECT: obtaining a composition for the treatment of cancer.

11 cl, 2 tbl, 15 ex

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RU 2 768 629 C2

Authors

Henry, Christophe

Dates

2022-03-24—Published

2018-08-31—Filed