NEW INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Russian patent published in 2023 - IPC C07D471/04 C07D487/22 C07F15/02 A61K31/437 A61K31/5377 A61P31/04 

FIELD: organic chemistry.

SUBSTANCE: compound of Formula I, a pharmaceutical composition containing it, and the use of this compound or pharmaceutical composition in the therapy and/or prevention of a bacterial infection. In Formula I, A is selected from the group consisting of optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, and optionally substituted alkenyl; R¹ is independently selected from the group consisting of H and optionally substituted alkyl; L is ; R^a and R^b are the same or different from each other and are independently selected from the group consisting of H, halogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroalkyl and optionally substituted heteroaryl, and R^a and R^b may optionally be connected together to form a carbocyclic or heterocyclic ring; the remaining substituent values are as defined in the claims.

I

EFFECT: compound of Formula I with inhibitory activity against bacterial glutamyl cyclases (bacQC).

12 cl, 10 dwg, 5 tbl, 29 ex