IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS TOLL-LIKE RECEPTOR AGONISTS Russian patent published in 2022 - IPC C07D471/04 A61K31/437 A61P35/00 

FIELD: pharmaceutical chemistry.

SUBSTANCE: inventions group relates to the field of pharmaceutical chemistry and includes a compound of formula (I) and a pharmaceutical composition based on it, where in formula (I) R¹ and R² are independently C_1-3 alkyl; or R¹ and R² are combined to form a 5-7 membered carbocyclic ring, wherein said carbocyclic ring may be saturated or unsaturated; R³ is ; R⁴ is C_1-6 alkyl or (CH₂)_nO(CH₂)_mCH₃, where C_1-6 alkyl or any carbon atom of the (CH₂)_nO(CH₂)_mCH₃ group is substituted with 0 to 3 halogens, as far as valence permits; R⁵ is C_1-3 alkyl or OC_1-3 alkyl, where C_1-3 alkyl is substituted with 0 to 3 F; R⁶ is H or C_1-3 alkyl, where C_1-3 alkyl is substituted with 0 to 3 F; m is 0-2; n is 1-3.

EFFECT: compound of formula (I) having TLR7/TLR8 agonist activity.

21 cl, 1 tbl, 19 ex