4-AMINO-IMIDAZOQUINOLINE DERIVATIVES, USEFUL IN TREATING DISEASES MEDIATED BY TLR7 AND/OR TLR8 AGONISTS Russian patent published in 2019 - IPC C07D471/04 A61K31/4188 A61P35/00 A61P31/00 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula I or a pharmaceutically acceptable salt thereof, where R¹ is C_1-7-alkyl or C_1-7-alkoxy-C_1-7-alkyl; R² is selected from a group consisting of hydrogen, halogen, C_1-7-alkoxycarbonyl-C_1-7-alkyl and C_1-7-alkoxycarbonyl-C_2-7-alkenyl; R³ is hydrogen; R⁴ is selected from a group consisting of -O-(CH₂)_m-NHR⁵ and -O-(CO)-(CH₂)_n-NHR⁶, where m is 2, n is 1, R⁵ is hydrogen and R⁶ is hydrogen. Invention also relates to specific compounds, a pharmaceutical composition based on the compound of formula I, use of the compound of formula I and a method of producing a compound of formula I.

EFFECT: technical result is obtaining novel 4-amino-imidazoquinoline derivatives useful in treating TLR7 and/or TLR8 agonist-mediated diseases.

13 cl, 11 ex