HETEROAROMATIC COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE MODULATORS AND METHODS OF USE Russian patent published in 2018 - IPC C07D471/04 C07D487/04 A61K31/5025 A61P35/00 

Abstract RU 2665036 C9

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically a heterocyclic compound of formula (I), where each of W1 and W3 is independently N or CRc; W2 represents CRc; Z represents CN or ; X represents H or (C1-C6)alkyl, where (C1-C6)alkyl is optionally substituted with 1 substituent independently selected from ORa; Y represents (C3-C6)cycloalkyl or (C6-C10)aryl, where (C6-C10)aryl is optionally substituted with 1 or 2 substituents independently selected from F; R1 represents Cl or ORa; Ra independently denotes H or (C1-C6)alkyl; and Rc is independently H. Also, the invention relates to the use of a compound of formula (I) and a pharmaceutical composition based on a compound of formula (I).

EFFECT: technical result: obtaining novel heterocyclic compounds useful in the treatment or prevention of a proliferative disorder.

14 cl, 7 tbl, 27 ex

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RU 2 665 036 C9

Authors

Xi Ning

Dates

2018-08-27Published

2013-11-10Filed