PHARMACEUTICAL COMBINATION, COMPOSITION, AND COMBINED FORMULATION CONTAINING A GLUCOKINASE ACTIVATOR AND A DPP-IV INHIBITOR, AND METHODS FOR PRODUCTION AND APPLICATION THEREOF Russian patent published in 2022 - IPC A61K31/4155 A61K31/437 A61K31/497 A61P3/10 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a hypoglycemic pharmaceutical combination containing (a) a glucokinase activator, constituting the HMS5552 compound, and (b) a DPP-IV inhibitor selected from the group consisting of sitagliptin, saxagliptin, and pharmaceutically acceptable salts thereof, wherein the mass ratio of the glucokinase activator and the DPP-IV inhibitor is from 1:10 to 100:1, the glucokinase activator is present at a dose from 1 to 200 mg, and the DPP-IV inhibitor is present at a dose in the range from 1 to 200 mg, as well as to a pharmaceutical composition and a fixed-dosage hypoglycemic combined formulation containing such a combination, an application thereof in the manufacture of a medicinal product, and a method for preventing, inhibiting the progression, delaying or treating one or multiple metabolic disorders selected from the group consisting of type I diabetes, type II diabetes, impaired glucose tolerance, fasting blood glucose disorders, hyperglycemia, post-meal hyperglycemia, excess body weight, obesity, hypertension, insulin resistance, and/or metabolic syndrome; or improving the control of blood glucose levels and/or reducing the fasting plasma glucose, post-meal plasma glucose, and/or glycosylated hemoglobin HbA1c.

EFFECT: production of a hypoglycemic pharmaceutical combination for treating metabolic disorders.

87 cl, 2 dwg, 11 tbl, 18 ex