FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely, to a method for assessing the development of ablation with irreversible electroporation and to a system for implementation thereof. A pair of electrodes of an ablative catheter is therein connected to the target tissue. A first bipolar signal with a first amplitude is received from the pair of electrodes at the first stage of the ablation procedure. The reception at the first stage includes receiving the first bipolar signal before applying an irreversible electroporation (IRE) pulse to the target tissue. A second bipolar signal with a second amplitude is received from the pair of electrodes at the second stage of the ablation procedure. The reception at the second stage includes receiving the second bipolar signal after applying an IRE pulse to the target tissue. The effectiveness of the ablation procedure is assessed based on the first and second amplitudes. The effectiveness assessment involves displaying (i) a first numerical difference between the first and second amplitudes and/or (ii) a second numerical difference between the second amplitude and the target threshold value.
EFFECT: accurate indication of execution of ablation is provided due to the visual indication of the development of the ablation procedure at each site with optimisation of the amount of IRE pulses applied to the tissue, thus the safety of the method for the patient is increased and the cycle of the ablation procedure is shortened; displaying the value of difference between the measured amplitude and the threshold value provides a possibility of controlling the application of pulses to the corresponding pairs of electrodes to form uniform damage along the target tissue at the site of ablation; indication of the difference between the amplitudes measured on the same pair of electrodes provides a possibility of visualising the effectiveness and rate of development of ablation in the area measured by one pair of electrodes, compared with the area measured by another pair of electrodes.
16 cl, 3 dwg
